Knowledgeable
Use case · Real-world evidence

Real-world evidence

Real-world evidence that lands with HTA reviewers.

Synthesise registry, claims and chart-review evidence into a defensible real-world evidence story, fit for the HTA body you are submitting to, with biases captured and limitations addressed before the reviewer raises them.

Reviewer-shaped
HTA-fit real-world evidence syntheses
Built-in
bias capture
Continuous
refresh cadence
Knowledgeable Live

Watch it run on your work.

Head of RWE · global team
A scripted demo · click Continue below (or press Space) to send the brief and walk through the work step by step.
Grounded in 12 sources · audit-logged
Head of RWE · global teamdraft
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Background & context

Where this fits in your workflow.

Synthesise registry, claims and chart-review evidence into a defensible real-world evidence story, fit for the HTA body you are submitting to, with biases captured and limitations addressed before the reviewer raises them.

Most teams running Real-world evidence today juggle a stack of search tools, PDF readers and consultancy slides, then spend the back half of the project reconciling claims to sources. Knowledgeable collapses that into one defensible workflow: real-world evidence that lands with hta reviewers.

The work runs against your literature, trial registries, HTA precedent, label and SmPC, with every sentence pinpoint-cited so your senior reviewer opens a document that's already at QC.

Evidence sources
Published literatureTrial registriesHTA precedentLabel / SmPCConference abstractsReal-world data
How it runs
  1. 1Scope & competing treatment locked
  2. 2Evidence pulled & graded
  3. 3Draft built with citations
  4. 4QC pass against framework
What changes

The work that finally lands the way you scoped it.

Registry, claims and chart-review unified

One synthesis across the data assets that actually exist for your indication, not a wishlist.

Unified view

Fit for HTA

Built against the specific real-world evidence expectations of NICE, G-BA, HAS. Not a generic summary.

HTA-shaped

Bias and limitations addressed

Confounders, indication creep and selection bias surfaced and addressed in-line.

Pre-empted

Continuous refresh

New publications and registry updates trigger an automatic flag and re-synthesis.

Live-monitored

Bring real-world evidence into the dossier on the reviewer's terms.

Audit your real-world evidence base
Responsible AI · Enterprise security

Built for HTA-grade real-world evidence.

Sources tracked, biases captured, limitations addressed. Audit-ready and reproducible.

EU AI Act alignedSSO + MFAAES-256 + TLS 1.2+EU / UK data residencyFull audit trail
Pre-answered for information security, medical and legal review, and procurement.